(Rac)-Idroxioleic acid-d17(Synonyms: 2-Hydroxyoleic acid-d17; 2-OHOA-d17)

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(Rac)-Idroxioleic acid-d17 (Synonyms: 2-Hydroxyoleic acid-d17; 2-OHOA-d17)

(Rac)-Idroxioleic acid-d17 (2-Hydroxyoleic acid-d17) 是 (Rac)-Idroxioleic acid 的氘代物。(Rac)-Idroxioleic acid (2-Hydroxyoleic acid) 是一种合成油酸 (OA) 衍生物,能与质膜结合改变脂质组织。(Rac)-Idroxioleic acid 具有抗肿瘤作用。

(Rac)-Idroxioleic acid-d17(Synonyms: 2-Hydroxyoleic acid-d17;  2-OHOA-d17)

(Rac)-Idroxioleic acid-d17 Chemical Structure

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生物活性

(Rac)-Idroxioleic acid-d17 (2-Hydroxyoleic acid-d17) is the deuterium labeled (Rac)-Idroxioleic acid. (Rac)-Idroxioleic acid (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. (Rac)-Idroxioleic acid has anti-tumor effect[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

315.57

Formula

C18H17D17O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70.

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