Pramipexole-d7 dihydrochloride(Synonyms: 盐酸普拉克索 d7 (双盐酸盐))

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Pramipexole-d7 dihydrochloride (Synonyms: 盐酸普拉克索 d7 (双盐酸盐))

Pramipexole-d7 dihydrochloride 是 Pramipexole dihydrochloride 的氘代物。Pramipexole dihydrochloride 是一种选择性的，具有血脑屏障 (BBB) 渗透性的 D2 型多巴胺受体 (dopamine D2-type receptor) 激动剂，对 D2 型受体、D2、D3、D4 亚型受体的 Ki 值分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。 Pramipexole dihydrochloride 可用于帕金森综合症和腿多动综合征的研究。

Pramipexole-d7 dihydrochloride(Synonyms: 盐酸普拉克索 d7 (双盐酸盐))

Pramipexole-d7 dihydrochloride Chemical Structure

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生物活性

Pramipexole-d7 dihydrochloride is the deuterium labeled Pramipexole dihydrochloride. Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson’s disease (PD) and restless legs syndrome (RLS)[1][2][3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

291.29

Formula

C10H12D7Cl2N3S
中文名称

盐酸普拉克索 d7 (双盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Kvernmo, T., et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78.

    [3]. Takashi Okura, et al. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci. 2007 Apr 3;80(17):1564-71.

    [4]. Ginetta Collo, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018; 2018: 4196961.

    [5]. P M Carvey, et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997;104(2-3):209-28.

    [6]. Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12(8): dmm033860.

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