Glycerol phenylbutyrate-D15(Synonyms: HPN-100-D15)

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Glycerol phenylbutyrate-D15 (Synonyms: HPN-100-D15)

Glycerol phenylbutyrate-D15 是Glycerol phenylbutyrate 的氘代标记物。Glycerol phenylbutyrate 是 sigma-2 (σ2) 受体的一个配体，其 pKi 值为 8.02。Glycerol phenylbutyrate (GPB) 也是氨清除剂。

Glycerol phenylbutyrate-D15(Synonyms: HPN-100-D15)

Glycerol phenylbutyrate-D15 Chemical Structure

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生物活性

Glycerol phenylbutyrate-D15 is a deuterium labeled Glycerol phenylbutyrate. Glycerol phenylbutyrate is a sigma-2 (σ2) receptor ligand, with a pKi of 8.02. Glycerol phenylbutyrate (GPB) is a new generation ammonia scavenger drug[1][2].

IC50 & Target

σ2 receptor[1].
体内研究
(In Vivo)

Glycerol phenylbutyrate (GPB) has the potential for the treatment of hyperammonemia. Glycerol phenylbutyrate (GPB) may have therapeutic potential in additional conditions such as chronic hepatic encephalopathy or other inherited metabolic disorders[1][2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

545.74

Formula

C33H23D15O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Rescifina A, et al. Development of a Sigma-2 Receptor affinity filter through a Monte Carlo based QSAR analysis. Eur J Pharm Sci. 2017 Aug 30;106:94-101.

    [2]. Oishi K, et al. Glycerol phenylbutyrate for the chronic management of urea cycle disorders. Expert Rev Endocrinol Metab. 2014 Sep;9(5):427-434.

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