Penciclovir-d4(Synonyms: BRL 39123-d4; VSA 671-d4)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Penciclovir-d4 (Synonyms: BRL 39123-d4; VSA 671-d4)

Penciclovir-d4 (BRL 39123-d4) 是 Penciclovir 的氘代物。Penciclovir 有效作用于 HSV1 和 2，IC₅₀ 分别为 0.04-1.8 μg/mL 和 0.06-4.4 μg/mL。

Penciclovir-d4 Chemical Structure

CAS No. : 1020719-72-5

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生物活性	Penciclovir-d4 (BRL 39123-d4) is the deuterium labeled Penciclovir. Penciclovir is reported to be potent against HSV types 1 and 2 with IC₅₀ of 0.04-1.8 μg/mL and 0.06-4.4 μg/mL, respectively^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	257.28
Formula	C₁₀H₁₁D₄N₅O₃
CAS 号	1020719-72-5
中文名称	喷昔洛韦 d4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Piret J, et al. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management. Antimicrob Agents Chemother. 2011 Feb;55(2):459-72. [3]. Xiong Z, et al. Imaging chemically modified adenovirus for targeting tumors expressing integrin alphavbeta3 in living micewith mutant herpes simplex virus type 1 thymidine kinase PET reporter gene. J Nucl Med. 2006 Jan;47(1):130-9.

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