Chlorthalidone-D4(Synonyms: 氯噻酮 D4)

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Chlorthalidone-D4 (Synonyms: 氯噻酮 D4)

Chlorthalidone-D4 是 Chlorthalidone 的氘代物。Chlorthalidone 是一种噻嗪类利尿剂，有潜力用于高血压的研究。

Chlorthalidone-D4 Chemical Structure

CAS No. : 1794941-44-8

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生物活性	Chlorthalidone-D4 is the deuterium labeled Chlorthalidone. Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	342.79
Formula	C₁₄H₇D₄ClN₂O₄S
CAS 号	1794941-44-8
中文名称	氯噻酮 D4
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Barrios V, et al. Which thiazide to choose as add-on therapy for hypertension? Integr Blood Press Control. 2014 Jul 30;7:35-47.;Ettinger B, et al. Chlorthalidone reduces calcium oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988 Apr;139(4):679-84.

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