Erlotinib-13C6(Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Erlotinib-13C6 (Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6)

Erlotinib-13C6 (CP-358774-13C6) 是一种 13C 标记的 Erlotinib。Erlotinib 是一种直接作用的 EGFR 酪氨酸激酶抑制剂，对人 EGFR 的 IC50 为 2 nM。

Erlotinib-13C6(Synonyms: CP-358774-13C6; NSC 718781-13C6; OSI-774-13C6)

Erlotinib-13C6 Chemical Structure

CAS No. : 1211107-68-4

规格 价格 是否有货
1 mg ￥15500 询问价格 & 货期

* Please select Quantity before adding items.

生物活性

Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1].

体外研究
(In Vitro)

Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

399.39

Formula

C1613C6H23N3O4
CAS 号

1211107-68-4
中文名称

埃罗替尼 13C6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Moyer JD, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res. 1997, 57(21), 4838-4848.

    [2]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务