Colcemid-d3(Synonyms: Demecolcine-d3)

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Colcemid-d3 (Synonyms: Demecolcine-d3)

Colcemid-d3 (Demecolcine-d3) 是 Colcemid 的氘代物。Colcemid (Demecolcine) 是一种有效的有丝分裂 (mitotic) 抑制剂。Colcemid 结合微管蛋白,并且可以阻滞细胞在中期进行核型分析。Colcemid 可诱导细胞凋亡 (apoptosis),可用于肿瘤研究。

Colcemid-d3(Synonyms: Demecolcine-d3)

Colcemid-d3 Chemical Structure

CAS No. : 1217668-72-8

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生物活性

Colcemid-d3 (Demecolcine-d3) is the deuterium labeled Colcemid. Colcemid (Demecolcine), a derivative of colchicine, is a potent mitotic inhibitor[1][2]. Colcemid binds to the protein tubulin and arrest cells in metaphase for karyotyping assays. Colcemid incuces cell apoptosis and can be used for cancer research[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

374.45

Formula

C21H22D3NO5

CAS 号

1217668-72-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. T Tsuchida, et al. Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle. Cytometry. 1998 Apr 1;31(4):295-9.

    [3]. Ashley M Rozario, et al. Ultra-Low Colcemid Doses Induce Microtubule Dysfunction as Revealed by Super-Resolution Microscopy. Bioexiv.

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