Sotalol-d6(Synonyms: MJ 1999-d6)

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Sotalol-d6 (Synonyms: MJ 1999-d6)

Sotalol D6 (MJ 1999-d6) 是 Sotalol 的氘代物。Sotalol 是一种口服有效，非选择性 β-肾上腺素受体 (β-adrenergic receptor) 阻断剂。Sotalol 具有抗心律失常作用，可用于小儿心律失常的研究。Sotalol 阻断 β受体和钾 KCNH2 通道，具有抗抗癫痫作用。

Sotalol-d6(Synonyms: MJ 1999-d6)

Sotalol-d6 Chemical Structure

CAS No. : 1246912-17-3

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生物活性

Sotalol D6 (MJ 1999-d6) is the deuterium labeled Sotalol. Sotalol is an orally active, non-selective β-adrenergic receptor blocker. Sotalol is a potent antiarrhythmic agent that can be used for the research of pediatric arrhythmias. Sotalol blocks β-receptors, and potassium KCNH2 channels. Antiepileptic Agent[1][2][3][4].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

278.40

Formula

C12H14D6N2O3S
CAS 号

1246912-17-3
中文名称

盐酸索他洛尔 d6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Marta Reyes-Corral, et al. Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. J Pharmacol Exp Ther. 2019 Apr;369(1):152-162.

    [3]. Xiaomei Li, et al. Pediatric Dosing of Intravenous Sotalol Based on Body Surface Area in Patients with Arrhythmia. Pediatr Cardiol. 2017 Oct;38(7):1450-1455.

    [4]. Kinga K Borowicz-Reutt, et al. Sotalol does not interfere with the antielectroshock action of selected second-generation antiepileptic drugs in mice.Pharmacol Rep. 2021 Apr;73(2):516-524.

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