Tolcapone D7(Synonyms: Ro 40-7592 D7)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Tolcapone D7 (Synonyms: Ro 40-7592 D7)

Tolcapone D7 (Ro 40-7592 D7) 是 Tolcapone 的氘代物。Tolcapone 是一种选择性，有效和口服的 COMT 抑制剂。Tolcapone 还是一种 α-syn 和 Aβ42 寡聚和原纤维形成的有效抑制剂，可防止 PC12 细胞中这两种蛋白质聚集引起的细胞外毒性。

Tolcapone D7(Synonyms: Ro 40-7592 D7)

Tolcapone D7 Chemical Structure

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生物活性

Tolcapone D7 (Ro 40-7592 D7) is a deuterium labeled Tolcapone. Tolcapone is a selective, potent and orally active COMT inhibitor. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis and protect against extracellular toxicity induced by the aggregation of both proteins in PC12 cells[1][2].

IC50 & Target

COMT[1]
α-syn and Aβ42 oligomerization, fibrillogenesis[2]
分子量

280.28

Formula

C14H4D7NO5
中文名称

托卡朋 D7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Paterson NE, et al. Sub-optimal performance in the 5-choice serial reaction time task in rats was sensitive to methylphenidate, atomoxetine and d-amphetamine, but unaffected by the COMT inhibitor tolcapone. Neurosci Res. 2011 Jan;69(1):41-50.

    [2]. Di Giovanni S, et al. Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J Biol Chem. 2010 May 14;285(20):14941-54.

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