Pregnanediol-d5(Synonyms: NSC 1612-d5; NSC 47462-d5)

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Pregnanediol-d5 (Synonyms: NSC 1612-d5; NSC 47462-d5)

Pregnanediol-d5 (NSC 1612-d5) 是 Pregnanediol 的氘代物。Pregnanediol 是黄体酮的主要代谢物 (metabolite)，可通过尿液排出。Pregnanediol 提供了一种间接测定体内孕激素水平的方法。

Pregnanediol-d5(Synonyms: NSC 1612-d5; NSC 47462-d5)

Pregnanediol-d5 Chemical Structure

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生物活性

Pregnanediol-d5 (NSC 1612-d5) is the deuterium labeled Pregnanediol. Pregnanediol is the major metabolite of progesterone and can be excreted via urine. Pregnanediol offers an indirect way to measure progesterone levels in vivo[1].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

325.54

Formula

C21H31D5O2
中文名称

孕二醇 d5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. H ROBERTSON, et al. Pregnanediol in the urine of the ewe. Nature. 1958 Nov 29;182(4648):1512-3.Sci Total Environ

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