Doxorubicinone-d3(Synonyms: Adriamycin aglycone-d3; Adriamycinone-d3)

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Doxorubicinone-d3 (Synonyms: Adriamycin aglycone-d3; Adriamycinone-d3)

Doxorubicinone-d3 (Adriamycin aglycone-d3) 是 Doxorubicinone 的氘代物。Doxorubicinone 是抗癌化疗药物阿霉素的代谢物。Doxorubicin 是一种有效的人 DNA 拓扑异构酶 I 和拓扑异构酶 II (topoisomerase l/II) 抑制剂,IC50 分别为 0.8 μM 和 2.67 μM。

Doxorubicinone-d3(Synonyms: Adriamycin aglycone-d3;  Adriamycinone-d3)

Doxorubicinone-d3 Chemical Structure

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生物活性

Doxorubicinone-d3 (Adriamycin aglycone-d3) is the deuterium labeled Doxorubicinone. Doxorubicinone is a metabolite of an anti-cancer chemotherapy agent Doxorubicin[1]. Doxorubicin is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

417.38

Formula

C21H15D3O9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. M Joerger, et al. Pharmacokinetics of low-dose doxorubicin and metabolites in patients with AIDS-related Kaposi sarcoma. Cancer Chemother Pharmacol. 2005 May;55(5):488-96.

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