Doxepin D3 Hydrochloride(Synonyms: 盐酸多塞平 D3)

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Doxepin D3 Hydrochloride (Synonyms: 盐酸多塞平 D3)

Doxepin D3 Hydrochloride 是 Doxepin Hydrochloride 的氘代物。Doxepin hydrochloride 是一种口服活性的三环抗抑郁药。Doxepin hydrochloride 是一种有效的选择性组胺受体 H1 拮抗剂。Doxepin hydrochloride 也是一种有效的 CYP450 抑制剂，并显着抑制 CYP450 2C19 和 CYP450 1A2。

Doxepin D3 Hydrochloride(Synonyms: 盐酸多塞平 D3)

Doxepin D3 Hydrochloride Chemical Structure

CAS No. : 347840-07-7

规格 价格 是否有货 数量
1 mg ￥1500 In-stock
5 mg ￥3700 In-stock
10 mg ￥6400 In-stock
50 mg   询价  
100 mg   询价  

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生物活性

Doxepin D3 Hydrochloride is a deuterium labeled Doxepin Hydrochloride. Doxepin hydrochloride is an orally active tricyclic antidepressant. Doxepin hydrochloride is a potent and selective histamine receptor H1 antagonist. Doxepin hydrochloride is also a potent CYP450 inhibitor and significantly inhibits CYP450 2C19 and 1A2[1][2].

IC50 & Target

Histamine receptor H1; CYP450 2C19 and CYP450 1A2[2]
分子量

318.86

Formula

C19H19D3ClNO
CAS 号

347840-07-7
中文名称

盐酸多塞平 D3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
参考文献

  • [1]. Hajak, G., et al., Doxepin in the treatment of primary insomnia: a placebo-controlled, double-blind, polysomnographic study. J Clin Psychiatry, 2001. 62(6): p. 453-63.

    [2]. Gillman PK1. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48.

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