Pergolide-d7 mesylate(Synonyms: Pergolide methanesulfonate-d7; LY127809-d7)

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Pergolide-d7 mesylate (Synonyms: Pergolide methanesulfonate-d7; LY127809-d7)

Pergolide-d7 mesylate (Pergolide methanesulfonate-d7) 是 Pergolide mesylate 的氘代物。Pergolide mesylate (Pergolide methanesulfonate),一种 Ergoline 衍生物,是一种有效的,具有口服活性的多巴胺 D1 和 D2 受体 (dopamine D1D2 receptors<

Pergolide-d7 mesylate(Synonyms: Pergolide methanesulfonate-d7;  LY127809-d7)

Pergolide-d7 mesylate Chemical Structure

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生物活性

Pergolide-d7 mesylate (Pergolide methanesulfonate-d7) is the deuterium labeled Pergolide mesylate. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson’s disease and hyperprolactinaemia research[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

417.64

Formula

C20H23D7N2O3S2

中文名称

甲磺酸培高利特 d7 (甲磺酸盐)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. S Franks, et al. Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia. Br Med J (Clin Res Ed). 1983 Apr 9;286(6372):1177-9.

    [3]. Daniela Uberti, et al. Pergolide protects SH-SY5Y cells against neurodegeneration induced by H(2)O(2). Eur J Pharmacol. 2002 Jan 2;434(1-2):17-20.

    [4]. Alin Ciobica, et al. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson’s disease. J Physiol Biochem. 2012 Mar;68(1):59-69.

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