Haloperidol-d4 N-Oxide(Synonyms: 氟哌啶醇 d4（N 氧化物）)

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Haloperidol-d4 N-Oxide (Synonyms: 氟哌啶醇 d4（N 氧化物）)

Haloperidol-d4 N-Oxide 是 Haloperidol 的氘代物。Haloperidol 是有效的 dopamine D2 receptor 拮抗剂，为一种安定药。

Haloperidol-d4 N-Oxide Chemical Structure

CAS No. : 1246815-56-4

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生物活性	Haloperidol-d4 N-Oxide is the deuterium labeled Haloperidol. Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic^[1]^[2].
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	395.89
Formula	C₂₁H₁₉D₄ClFNO₃
CAS 号	1246815-56-4
中文名称	氟哌啶醇 d4（N 氧化物）
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Furuta Y, et al. Effects of enzyme inhibitors of catecholamine metabolism and of haloperidol on the pancreatic secretion induced by L-DOPA and by dopamine in dogs. Br J Pharmacol. 1973 Jan;47(1):77-84 [3]. Shah NS, et al. Effects of chlorpromazine and haloperidol on the disposition of mescaline-14C in mice. J Pharmacol Exp Ther. 1973 Aug;186(2):297-304

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