Amantadine-d15(Synonyms: 1-Adamantanamine-d15; 1-Aminoadamantane-d15)

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Amantadine-d15 (Synonyms: 1-Adamantanamine-d15; 1-Aminoadamantane-d15)

Amantadine-d15 (1-Adamantanamine-d15) 是 Amantadine 的氘代物。Amantadine (1-Adamantanamine) 是一种抗甲型流感 (influenza A) 病毒的抗病毒药物。Amantadine 阻断质子流通过 M2 离子通道 (M2 proton channel of influenza A)，从而阻止病毒 RNA 释放到感染细胞的细胞质中。Amantadine 抗帕金森病剂。

Amantadine-d15(Synonyms: 1-Adamantanamine-d15; 1-Aminoadamantane-d15)

Amantadine-d15 Chemical Structure

CAS No. : 33830-10-3

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生物活性

Amantadine-d15 (1-Adamantanamine-d15) is the deuterium labeled Amantadine. Amantadine (1-Adamantanamine) is an antiviral agent with activity against influenza A viruses. Amantadine blocks the proton flow through the M2 ion channel (M2 proton channel of influenza A) and thus prevents the release of viral RNA into the cytoplasm of the infected cells. Amantadine is an antiparkinsonian agent[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

166.34

Formula

C10H2D15N
CAS 号

33830-10-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.

    [3]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 2012;78(14):1096-1099.

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