Eliglustat-d15 tartrate(Synonyms: Genz 99067-d15 tartrate)

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Eliglustat-d15 tartrate (Synonyms: Genz 99067-d15 tartrate)

Eliglustat-d15 (Genz 99067-d15) tartrate 是 Eliglustat tartrate 的氘代物。Eliglustat tartrate 是高效特异，有口服活性的葡糖脑苷脂合成酶抑制剂，IC50值为24 nM。

Eliglustat-d15 tartrate(Synonyms: Genz 99067-d15 tartrate)

Eliglustat-d15 tartrate Chemical Structure

CAS No. : 1884556-84-6

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生物活性

Eliglustat-d15 (Genz 99067-d15) tartrate is the deuterium labeled Eliglustat. Eliglustat tartrate is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

569.72

Formula

C27H27D15N2O10
CAS 号

1884556-84-6
中文名称

依利格鲁司特 d15 (酒石酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91(3):259-68.

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