Penicillamine-d3(Synonyms: D-(-)-Penicillamine-d3)

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Penicillamine-d3 (Synonyms: D-(-)-Penicillamine-d3)

Penicillamine-d3 (D-(-)-Penicillamine-d3) 是 Penicillamine 的氘代物。Penicillamine (D-(-)-Penicillamine) 是 penicillin 的代谢降解产物，可作为螯合剂，作用于威尔逊氏病。

Penicillamine-d3(Synonyms: D-(-)-Penicillamine-d3)

Penicillamine-d3 Chemical Structure

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生物活性

Penicillamine-d3 (D-(-)-Penicillamine-d3) is the deuterium labeled Penicillamine. Penicillamine (D-(-)-Penicillamine) is the most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson’s disease.

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

152.23

Formula

C5H8D3NO2S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Peisach, J. and W.E. Blumberg, A mechanism for the action of penicillamine in the treatment of Wilson’s disease. Mol Pharmacol, 1969. 5(2): p. 200-9.

    [3]. Jaffe, I.A., K. Altman, and P. Merryman, The Antipyridoxine Effect of Penicillamine in Man. J Clin Invest, 1964. 43: p. 1869-73.

    [4]. Camp, A.V., Penicillamine in the treatment of rheumatoid arthritis. Proc R Soc Med, 1977. 70(2): p. 67-9.

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