Imipramine-d4 hydrochloride(Synonyms: 盐酸丙咪嗪 d4 (盐酸盐))

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Imipramine-d4 hydrochloride (Synonyms: 盐酸丙咪嗪 d4 (盐酸盐))

Imipramine-d4 hydrochloride 是 Imipramine hydrochloride 的氘代物。Imipramine hydrochloride 抑制血清素转运蛋白(serotonin)，IC50 值为 32 nM。Imipramine hydrochloride 可阻止胰酶的易位，抑制 MV 和外泌体的分泌。

Imipramine-d4 hydrochloride(Synonyms: 盐酸丙咪嗪 d4 (盐酸盐))

Imipramine-d4 hydrochloride Chemical Structure

CAS No. : 61361-33-9

规格 是否有货
2.5 mg Check price and availability
1 mg Check price and availability
5 mg Check price and availability
10 mg Check price and availability

* Please select Quantity before adding items.

生物活性

Imipramine-d4 hydrochloride is the deuterium labeled Imipramine hydrochloride. Imipramine hydrochloride inhibits serotonin transporter with an IC50 value of 32 nM. Imipramine hydrochloride is reported to prevent the translocation of aSMase, inhibiting MV and exosomes secretion[1][2][3][4][5].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

320.89

Formula

C19H21D4ClN2
CAS 号

61361-33-9
中文名称

盐酸丙咪嗪 d4 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Balkovetz DF, et al. Evidence for an imipramine-sensitive serotonin transporter in human placental brush-border membranes. J Biol Chem. 1989 Feb 5;264(4):2195-8.

    [3]. Yasuda S, et al. Imipramine ameliorates pain-related negative emotion via induction of brain-derived neurotrophic factor. Cell Mol Neurobiol. 2014 Nov;34(8):1199-208.

    [4]. Ramirez K, et al. Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance. Brain Behav Immun. 2015 May;46:212-20.

    [5]. Erburu M, et al. Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse prefrontal cortex. Pharmacol BiochemBehav. 2015 Aug;135:227-36.

    [6]. Nagasawa M, et al. Chronic imipramine treatment differentially alters the brain and plasma amino acid metabolism in Wistar and Wistar Kyoto rats. Eur J Pharmacol. 2015 Sep 5;762:127-35.

    [7]. Tokarski K, et al. Imipramine counteracts corticosterone-induced alterations in the effects of the activation of 5-HT(7) receptors in rat hippocampus. J Physiol Pharmacol. 2009 Jun;60(2):83-8.

    [8]. Mariadelva Catalano, et al. Inhibiting extracellular vesicles formation and release: a review of EV inhibitors. J Extracell Vesicles. 2020; 9(1): 1703244.

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务