Umifenovir-d6 hydrochloride(Synonyms: 盐酸阿比朵尔 d6 (盐酸盐))

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Umifenovir-d6 hydrochloride (Synonyms: 盐酸阿比朵尔 d6 (盐酸盐))

Umifenovir-d6 hydrochloride 是 Umifenovir hydrochloride 的氘代物。Umifenovir hydrochloride 是一种有效的口服广谱抗病毒药物，对多种包膜和非包膜病毒均有活性。Umifenovir hydrochloride 被用作抗流感病毒 (anti-influenza virus) 剂。Umifenovir hydrochloride 能有效抑制病毒与宿主细胞的融合。Umifenovir hydrochloride 是一种有效的

Umifenovir-d6 hydrochloride(Synonyms: 盐酸阿比朵尔 d6 (盐酸盐))

Umifenovir-d6 hydrochloride Chemical Structure

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生物活性

Umifenovir-d6 hydrochloride is the deuterium labeled Umifenovir hydrochloride. Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells[1][2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

519.91

Formula

C22H20D6BrClN2O3S
中文名称

盐酸阿比朵尔 d6 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. Boriskin YS, et al. Arbidol: a broad-spectrum antiviral compound that blocks viral fusion. Curr Med Chem. 2008;15(10):997-1005.

    [3]. Liu Q, et al. Antiviral and anti-inflammatory activity of arbidol hydrochloride in influenza A (H1N1) virus infection. Acta Pharmacol Sin. 2013;34(8):1075-1083.

    [4]. Wang X, et al. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. Cell Discov. 2020;6:28. Published 2020 May 2.

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