Barnidipine-d5 hydrochloride(Synonyms: Mepirodipine-d5 hydrochloride; YM-09730-5-d5 hydrochloride)

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Barnidipine-d5 hydrochloride (Synonyms: Mepirodipine-d5 hydrochloride; YM-09730-5-d5 hydrochloride)

Barnidipine-d5 (Mepirodipine-d5) hydrochloride 是 Barnidipine hydrochloride 的氘代物。Barnidipine (Mepirodipine) hydrochloride 巴尼地平是一种 L 型钙拮抗剂 (CaA)，对 [3H] initrendipine 结合位点具有高亲和力 (Ki=0.21 nmol/l)，对 CaA 受体具有选择性作用。Barnidipine (Mepirodipine) hydrochloride 是一种抗高血压药物，通过减少其血管扩张作用继发的外周血管阻力起作用。

Barnidipine-d5 hydrochloride(Synonyms: Mepirodipine-d5 hydrochloride; YM-09730-5-d5 hydrochloride)

Barnidipine-d5 hydrochloride Chemical Structure

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生物活性

Barnidipine-d5 (Mepirodipine-d5) hydrochloride is the deuterium labeled Barnidipine hydrochloride. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an L-type calcium antagonist (CaA) with high affinity for [3H] initrendipine binding sites (Ki=0.21 nmol/l), has selective action against CaA receptors[1]. Barnidipine hydrochloride (Mepirodipine hydrochloride) is an antihypertensive drug and acts by the reduction of peripheral vascular resistance secondary to its vasodilatory action[2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

533.03

Formula

C27H25D5ClN3O6
中文名称

盐酸巴尼地平 d5 (盐酸盐)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

    [2]. van Zwieten PA, et al. Pharmacological profile of barnidipine: a single optical isomer dihydropyridine calcium antagonist. Blood Press Suppl. 1998;1:5-8.

    [3]. Malhotra HS, et al. Barnidipine. Drugs. 2001;61(7):989-96; discussion 997-8.

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