Palbociclib-d8(Synonyms: PD 0332991-d8)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Palbociclib-d8 (Synonyms: PD 0332991-d8) 纯度: 99.84%

Palbociclib D8 (PD 0332991 D8) 是 Palbociclib 的氘代物。Palbociclib 是一种选择性的口服活性的 CDK4 和 CDK6 抑制剂，IC₅₀ 分别为 11 nM 和 16 nM。Palbociclib 有潜力用于 ER 阳性和 HER2 阴性乳腺癌的研究。

Palbociclib-d8 Chemical Structure

CAS No. : 1628752-83-9

规格	价格	是否有货
1 mg	￥3200	In-stock
5 mg		询价
10 mg		询价

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生物活性

Palbociclib D8 (PD 0332991 D8) is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active CDK4 and CDK6 inhibitor with IC₅₀s of 11 and 16 nM, respectively. Palbociclib has the potential for ER-positive and HER2-negative breast cancer research^[1].

IC₅₀ & Target

Cdk4/cyclin D3

9 nM (IC₅₀)

Cdk4/cyclin D1

11 nM (IC₅₀)

Cdk6/cyclin D2

16 nM (IC₅₀)

DYRK1A

2000 nM (IC₅₀)

MAPK

8000 nM (IC₅₀)

分子量

455.58

Formula

C₂₄H₂₁D₈N₇O₂

CAS 号

1628752-83-9

中文名称

帕布昔利布 d8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

参考文献

[1]. Fry DW, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004 Nov;3(11):1427-38.

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