Ticlopidine-d4 hydrochloride(Synonyms: 盐酸噻氯匹定 d4 (盐酸盐))

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Ticlopidine-d4 hydrochloride (Synonyms: 盐酸噻氯匹定 d4 (盐酸盐))

Ticlopidine-d4 hydrochloride 是 Ticlopidine hydrochloride 的氘代物。Ticlopidine hydrochloride 是 ADP 受体抑制剂，对血小板凝集的 IC₅₀ 为 2 μM。

Ticlopidine-d4 hydrochloride Chemical Structure

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生物活性	Ticlopidine-d4 hydrochloride is the deuterium labeled Ticlopidine hydrochloride. Ticlopidine hydrochloride is an adenosine diphosphate (ADP) receptor inhibitor against platelet aggregation with IC₅₀ of ~2 μM.
体外研究 (In Vitro)	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	304.27
Formula	C₁₄H₁₁D₄Cl₂NS
中文名称	盐酸噻氯匹定 d4 (盐酸盐)
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Thebault JJ, et al. Effects of ticlopidine, a new platelet aggregation inhibitor in man. Clin Pharmacol Ther. 1975 Oct;18(4):485-90. [3]. Ashida SI, et al. Mode of action of ticlopidine in inhibition of platelet aggregation in the rat. Thromb Haemost. 1979 Apr 23;41(2):436-49.

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