Ascamycin

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Ascamycin 

Ascamycin 是一种由链霉菌属 (Streptomyces sp. JCM9888) 产生的 5′-O-磺酰胺核糖核苷抗生素。Ascamycin 对 Xanthomonas 菌具有选择性的抑菌活性，对 Xanthomonas citri，Xanthomonas oryzae 和 Mycobacterium phlei 的 MIC 值分别为 0.4 μg/mL，12.5 μg/mL 和 12.5 μg/mL。

Ascamycin

Ascamycin Chemical Structure

CAS No. : 91432-48-3

规格 价格 是否有货 数量
1 mg ￥3995 1 周
5 mg 询价
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25 mg 询价

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Ascamycin 相关产品

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生物活性

Ascamycin is a 5′-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against Xanthomonas species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for Xanthomonas citri, Xanthomonas oryzae and Mycobacterium phlei, respectively[1][2][3].

IC50 & Target

MIC: 0.4 μg/mL (Xanthomonas citri), 12.5 μg/mL (Xanthomonas oryzae) and 12.5 μg/mL (Mycobacterium phlei)[1]
体外研究
(In Vitro)

The Ascamycin has C2-chloroadenine as the base on C-1′ which lacks the chlorine[1]. Ascamycin has a selective antibacterial activity against Xanthomonas species. When Ascamycin is dealanylated, Dealanylascamycin shows a broad antibacterial activity against various Gram-negative and Gram-positive bacteria. Xanthomonas citri is susceptible to Ascamycin by virtue of the Ascamycin-dealanylating enzyme on the cell surface[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Ascamycin 相关抗体:
分子量

451.84

Formula

C13H18ClN7O7S
CAS 号

91432-48-3
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

Streptomyces sp
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (542 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Isono K, et al. Ascamycin and dealanylascamycin, nucleoside antibiotics from Streptomyces sp. J Antibiot (Tokyo). 1984 Jun;37(6):670-2.  [Content Brief]

    [2]. Osada H, rt al. Purification and characterization of ascamycin-hydrolysing aminopeptidase from Xanthomonas citri. Biochem J. 1986 Jan 15;233(2):459-63.  [Content Brief]

    [3]. Zhao C, et al. Characterization of biosynthetic genes of ascamycin/dealanylascamycin featuring a 5′-O-sulfonamide moiety in Streptomyces sp. JCM9888. PLoS One. 2014 Dec 5;9(12):e114722.  [Content Brief]

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