Tirandamycin A (Synonyms: 替达霉素A)

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Tirandamycin A  (Synonyms: 替达霉素A)

Tirandamycin A, 一种抗生素， 是一种细菌 RNA 聚合酶 (bacterial RNA polymerase) 抑制剂。Tirandamycin A 具有抗阿米巴原虫和抗菌性能。

Tirandamycin A (Synonyms: 替达霉素A)

Tirandamycin A Chemical Structure

CAS No. : 34429-70-4

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Tirandamycin A 相关产品

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生物活性

Tirandamycin A, an antibiotic, is a bacterial RNA polymerase inhibitor. Tirandamycin A has antiamoebic and antibacterial properties[1][2].

IC50 & Target

Amebae

 

体外研究
(In Vitro)

A 60 μM treatment with Tirandamycin A results in a slightly stronger inhibition, demonstrating a 84.2% reduction in growth of Entamoeba histolytica HM-1:IMSS and 64.8% reduction in growth by Entamoeba histolytica Col. Tirandamycin A inhibits chain initiation and elongation of bacterial RNA polymerase without acting on mammalian polymerases[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Tirandamycin A 相关抗体:
分子量

417.45

Formula

C22H27NO7
CAS 号

34429-70-4
中文名称

替达霉素A
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Disease Research
  • Anti-parasitic
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

Streptomyces flaveolus strain Tu 1240
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (527 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Avelina Espinosa, et al. Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A. Parasitol Res. 2012 Dec;111(6):2473-7.  [Content Brief]

    [2]. H Hagenmaier, et al. Metabiolic products of microorganisms. Tirandamycin B(author’s transl). Arch Microbiol. 1976 Aug;109(1-2):65-74.  [Content Brief]

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