Absinthin (Synonyms: 洋艾素)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Absinthin  (Synonyms: 洋艾素)

Absinthin 是一种结构独特的三萜类化合物，这是艾草苦味高的原因。Absinthin 是苦味受体 hTAS2R46 的一种激动剂，它通过 hTAS2R46 介导的受体特异性机制降低组胺诱导的细胞内 Ca2+ 升高。

Absinthin (Synonyms: 洋艾素)

Absinthin Chemical Structure

CAS No. : 1362-42-1

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Absinthin 相关产品

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生物活性

Absinthin is a structurally unique triterpene, and is responsible for the high bitter value of wormwood. Absinthin is an agonist of the bitter taste receptor hTAS2R46, which reduces cytosolic Ca2+-rises induced by histamine by a receptor-specific mechanism mediated by hTAS2R46[1][2][3].

体外研究
(In Vitro)

Absinthin (10 μM, 60 s)通过 hTAS2R46 抑制气道平滑肌 (ASM) 细胞中组胺诱导的 Ca2+ 增加[3]。
Absinthin (1 和 10 μM，1 h 或 18 h) 显示抗氧化活性，并抑制 BEAS-2B 细胞中 PMA (HY-18739) 诱导的超氧阴离子产生(1 小时)和 iNOS 表达 (18 小时)[5 ]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Absinthin 相关抗体:
体内研究
(In Vivo)

Absinthin (20-80mg/kg, 口服) 可缓解 LPS 引起的急性肺损伤 (减少炎症细胞浸润并改善 小鼠的肺结构)[4]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced acute lung injury in mice[4]
Dosage: 20, 40, 80mg/kg
Administration: p.o.
Result: Reduced inflammatory cell infiltration and improved lung architecture.
Reduced MPO activity, infiltration of neutrophils, lung tissue wet-to-dry ratio.
Reduced the secretion of proinflammatory cytokines and chemokines (TNF-α, IL-1β, IL-6 , and MIP-1α).

分子量

496.64

Formula

C30H40O6
CAS 号

1362-42-1
中文名称

洋艾素
结构分类
  • Terpenoids
  • Triterpenes
初始来源
  • 植物
  • 豆科
  • 台湾相思
  • 植物
  • 菊科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Zhang W, et al. Total synthesis of absinthin. J Am Chem Soc. 2005 Jan 12;127(1):18-9.  [Content Brief]

    [2]. Lachenmeier DW, et al. Absinthe–a review. Crit Rev Food Sci Nutr. 2006;46(5):365-77.  [Content Brief]

    [3]. Talmon M, et al. Absinthin, an agonist of the bitter taste receptor hTAS2R46, uncovers an ER-to-mitochondria Ca2+-shuttling event. J Biol Chem. 2019 Aug 16;294(33):12472-12482.  [Content Brief]

    [4]. Guo N, et al. Absinthin attenuates LPS-induced ALI through MIP-1α-mediated inflammatory cell infiltration. Exp Lung Res. 2015;41(9):514-24.  [Content Brief]

    [5]. Talmon M, et al. Anti-inflammatory Activity of Absinthin and Derivatives in Human Bronchoepithelial Cells. J Nat Prod. 2020 Jun 26;83(6):1740-1750.  [Content Brief]

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