Secalonic acid D

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Secalonic acid D 

Secalonic acid D 是一种抗肿瘤细胞的有毒化合物。Secalonic acid D可以从 Aspergillus aculeatus 的代谢产物中分离得到。Secalonic acid D 激活 GSK3-β，并降解 β-catenin。因此，Secalonic acid D 下调 c-Myc 表达，使细胞周期停滞在 G1 期，诱导细胞凋亡 (apoptosis)。

Secalonic acid D

Secalonic acid D Chemical Structure

CAS No. : 35287-69-5

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生物活性

Secalonic acid D is a toxic compound against tumor cells. Secalonic acid D can be isolated from the metabolites of Aspergillus aculeatus. Secalonic acid D activates GSK3-β, and degrades β-catenin. Thus, Secalonic acid D down-regulates c-Myc expression, arrests cell cycle at G1 phase, induces cell apoptosis[1][2].

体外研究
(In Vitro)

Secalonic acid D (0.1-1 μM; 72 h) 在 HL60 和 K562 中以浓度依赖性方式抑制细胞增殖，IC50 分别为 0.38 μM 和 0.43 μM[1]。
Secalonic acid D (0.3 μM; 12 h, 24 h) 导致细胞周期停滞在 G1 期，(1.2 μM; 0-72 h) 并诱导 HL60 和 K562 细胞凋亡[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Secalonic acid D 相关抗体:

Apoptosis Analysis[1]

Cell Line: HL60 and K562 cells
Concentration: 1.2 μM
Incubation Time: 0, 24, 48 and 72 h
Result: Induced cell apoptosis via arresting cell cycle at G1 phase. As well as, down-regulated the expression level of c-Myc.

Western Blot Analysis[1]

Cell Line: HL60 and K562 cells
Concentration: 1.2 μM
Incubation Time: 0, 24, 48 and 72 h
Result: Dose-dependently decreases the level of Caspase-1.

分子量

638.57

Formula

C32H30O14
CAS 号

35287-69-5
结构分类
  • Others
初始来源
  • 微生物

aspergillus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (535 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Andersen R, et al. Secalonic acids D and F are toxic metabolites of Aspergillus aculeatus. J Org Chem. 1977 Jan 21;42(2):352-3.  [Content Brief]

    [2]. Zhang JY, et al. Secalonic acid D induced leukemia cell apoptosis and cell cycle arrest of G(1) with involvement of GSK-3beta/beta-catenin/c-Myc pathway. Cell Cycle. 2009 Aug;8(15):2444-50.  [Content Brief]

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