Monactin

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Monactin 

Monactin 是一种抗生素，也是单价阳离子 (包括钾、钠和锂) 的非选择性离子载体。Monactin 是从链霉菌中分离出来，并具有抗增殖活性。

Monactin

Monactin Chemical Structure

CAS No. : 7182-54-9

规格 价格 是否有货 数量
5 mg 询价
1 mg ￥5724 3 – 4 周

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生物活性

Monactin is a mactrotetralide antibiotic and a non-selective ionophore for monovalent cations, including potassium, sodium, and lithium. Monactin is isolated from Streptomyces and has antiproliferative activity[1][2][3].

体外研究
(In Vitro)

Monactin displays strong antiproliferative activity against A2780 ovarian cancer cells (IC50 0.13 μM), A2058 melanoma cells (0.02 μM), and H522-T1 non small-cell cancer lung cells (0.01 μM)[3].
Monactin inhibits TCF/β-catenin transcriptional activity[4].
At a concentration of 10 μM, nigericin and monactin inhibited growth of Streptococcus faecalis, and the inhibition was reversed by addition of excess K(+)[5].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Monactin 相关抗体:
体内研究
(In Vivo)

Monactin is potent uncoupler of oxidative phosphorylation and inducer of ATP hydrolysis in rat liver mitochondria[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

750.96

Formula

C41H66O12
CAS 号

7182-54-9
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Disease Research
  • Anticancer
  • Antibiotics
  • Macrolide Antibiotics
初始来源
  • 微生物

Streptomyces griseus
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (538 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Graven SN, et al. Antibiotics as tools for metabolic studies. VI. Damped oscillatory swelling of mitochondria induced by nonactin, monactin, dinactin, and trinactin. Biochemistry. 1966;5(5):1735-1742.  [Content Brief]

    [2]. Murer H, et al. On the mechanism of sugar and amino acid interaction in intestinal transport. J Biol Chem. 1975;250(18):7392-7396.  [Content Brief]

    [3]. Harinantenaina Rakotondraibe L, et al. Antiproliferative and antiplasmodial compounds from selected Streptomyces species. Bioorg Med Chem Lett. 2015;25(23):5646-5649.  [Content Brief]

    [4]. Tamai, Y, et al. Nonactin and related compounds found in a screening program for wnt signal inhibitory activity. Heterocycles, 84(2), 1245-1250.

    [5]. Harold FM, et al. Effects of nigericin and monactin on cation permeability of Streptococcus faecalis and metabolic capacities of potassium-depleted cells. J Bacteriol. 1968;95(3):816-823.  [Content Brief]

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