Acetyl coenzyme A (Synonyms: Acetyl-CoA)

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Acetyl coenzyme A  (Synonyms: Acetyl-CoA)

Acetyl-coenzyme A (Acetyl-CoA) 是一种具有膜非渗透性的中枢代谢中间体，参与 TCA 循环和氧化磷酸化代谢过程。Acetyl-coenzyme A 通过向目标氨基酸残基提供 (唯一供体) 乙酰基团，来完成蛋白质的翻译后乙酰化反应，从而调节各种细胞机制。Acetyl Coenzyme A 也是脂质合成的关键前体。

Acetyl coenzyme A (Synonyms: Acetyl-CoA)

Acetyl coenzyme A Chemical Structure

CAS No. : 72-89-9

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Acetyl coenzyme A 的其他形式现货产品:

Acetyl Coenzyme A trisodium

Acetyl coenzyme A 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Acetyl-coenzyme A (Acetyl-CoA) is a membrane-impermeant central metabolic intermediate, participates in the TCA cycle and oxidative phosphorylation metabolism. Acetyl-coenzyme A, regulates various cellular mechanisms by providing (sole donor) acetyl groups to target amino acid residues for post-translational acetylation reactions of proteins. Acetyl Coenzyme A is also a key precursor of lipid synthesis[1][2][3][4].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Acetyl coenzyme A 在饥饿的 U2OS 细胞中增加细胞质蛋白乙酰化，同时减少饥饿诱导的自噬通量。(U2OS 细胞稳定表达 GFP-LC3 并显微注射Acetyl coenzyme A; 在无营养条件下，用 100 nM BafA1 孵育 3 h 后固定)[2]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Acetyl coenzyme A 相关抗体:
体内研究
(In Vivo)

Acetyl coenzyme A 通过抑制适应不良的自噬来抑制压力超负荷诱导的小鼠心肌病[2][3]。 被剥夺食物 (但可以随意饮水) 24 小时的小鼠在几个器官 (包括心脏和肌肉) 中表现出总 Acetyl coenzyme A 水平显着降低，对应于蛋白质乙酰化水平的降低。相同的实验条件对大脑中 Acetyl coenzyme A 的浓度没有重大影响，实际上会增加肝脏 Acetyl coenzyme A 和蛋白质乙酰化水平[4]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

809.57

Formula

C23H38N7O17P3S
CAS 号

72-89-9
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (537 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Choudhary C, et al. The growing landscape of lysine acetylation links metabolism and cell signalling. Nat Rev Mol Cell Biol. 2014 Aug;15(8):536-50.  [Content Brief]

    [2]. Mariño G, et al. Regulation of autophagy by cytosolic acetyl-coenzyme A. Mol Cell. 2014 Mar 6;53(5):710-25.  [Content Brief]

    [3]. Zhu H, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest. 2007 Jul;117(7):1782-93.  [Content Brief]

    [4]. Pietrocola F, et al. Acetyl coenzyme A: a central metabolite and second messenger. Cell Metab. 2015 Jun 2;21(6):805-21.  [Content Brief]

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