S-(2,4-Dinitrophenyl)glutathione

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S-(2,4-Dinitrophenyl)glutathione 

S-(2,4-Dinitrophenyl)glutathione 是谷胱甘肽-S-转移酶的底物。S-(2,4-Dinitrophenyl)glutathione 可用作不可逆的谷胱甘肽还原酶 (glutathione reductase) 抑制剂，Ki 值为30 µM。

S-(2,4-Dinitrophenyl)glutathione

S-(2,4-Dinitrophenyl)glutathione Chemical Structure

CAS No. : 26289-39-4

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生物活性

S-(2,4-Dinitrophenyl)glutathione is a substrate for glutathione-S-transferase. (2,4-Dinitrophenyl)glutathione can be used as an irreversible glutathione reductase inhibitor with an Ki value of 30 µM[1][2].

IC50 & Target

Ki: 30 µM(glutathione reductase)[2]
分子量

473.41

Formula

C16H19N5O10S
CAS 号

26289-39-4
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (528 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Yokooji T, et al. Site-specific bidirectional efflux of 2,4-dinitrophenyl-S-glutathione, a substrate of multidrug resistance-associated proteins, in rat intestine and Caco-2 cells. J Pharm Pharmacol. 2007 Apr;59(4):513-20.  [Content Brief]

    [2]. Bilzer M, et al. Interaction of a glutathione S-conjugate with glutathione reductase. Kinetic and X-ray crystallographic studies. Eur J Biochem. 1984 Jan 16;138(2):373-8.  [Content Brief]

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