Folinic acid disodium (Synonyms: Leucovorin disodium)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Folinic acid disodium  (Synonyms: Leucovorin disodium)

Folinic acid (Leucovorin) disodium 是一种生物叶酸，是维生素 B9 的一种形式。Folinic acid disodium 通常与 Methotrexate (MTX) (HY-14519) 作为救援剂一起给药，以降低 MTX 诱导的毒性。Folinic acid disodium 和氟尿嘧啶辅助化疗对结肠癌有效。

Folinic acid disodium (Synonyms: Leucovorin disodium)

Folinic acid disodium Chemical Structure

CAS No. : 163254-40-8

规格 是否有货
5 mg 询价
10 mg 询价
50 mg 询价
100 mg 询价

* Please select Quantity before adding items.

Folinic acid disodium 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Folinic acid (Leucovorin) disodium is a biological folic acid and is a forms of vitamin B9. Folinic acid disodium is generally administered along with Methotrexate (MTX) (HY-14519) as a rescue agent to decrease MTX-induced toxicity. Folinic acid disodium and Sfluorouracil adjuvant chemotherapy shows effective in colon carcinoma[1][2][3].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Folinic acid disodium (5, 50 µg/ml; 40 h) significantly reduces % micronucleated binucleated cells (MNBN) (40%-68%) and % aberrant cells (Abs) (36%-77%) in V79 cells that were treated with MTX at five different concentrations 5–100 mg/ml for 6 h[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Folinic acid disodium 相关抗体:
体内研究
(In Vivo)

Folinic acid disodium (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following Methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2]
Dosage: 7.0 mg/kg
Administration: Intraperitoneal injection; every second day; for 3 weeks
Result: Following MTX administration appears to reverse this growth inhibition.

Clinical Trial

分子量

517.40

Formula

C20H21N7Na2O7
CAS 号

163254-40-8
中文名称

亚叶酸二钠盐
结构分类
  • Others
初始来源
  • 内源性代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (533 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Keshava, C., et al., Inhibition of methotrexate-induced chromosomal damage by folinic acid in V79 cells. Mutat Res, 1998. 397(2): p. 221-8.  [Content Brief]

    [2]. Iqbal MP, et al. Effect of methotrexate and folinic acid on skeletal growth in mice. Acta Paediatr. 2003 Dec;92(12):1438-44.  [Content Brief]

    [3]. Francini G, et al. Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer. Gastroenterology. 1994 Apr;106(4):899-906.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务