Methyldopa (Synonyms: 甲基多巴; L-(-)-α-Methyldopa; MK-351)

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Methyldopa  (Synonyms: 甲基多巴; L-(-)-α-Methyldopa; MK-351)

Methyldopa (L-(-)-α-Methyldopa) 是一种 α-肾上腺素能激动剂 (对 α2- adrenergic receptors 有选择性)。Methyldopa 是一种前体，在中枢神经系统中被代谢 (α-Methylepinephrine)。

Methyldopa (Synonyms: 甲基多巴; L-(-)-α-Methyldopa; MK-351)

Methyldopa Chemical Structure

CAS No. : 555-30-6

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Methyldopa 的其他形式现货产品:

Methyldopa hydrate

Methyldopa 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Methyldopa (L-(-)-α-Methyldopa), a potent antihyoertensive agent, is an alpha-adrenergic agonist (selective for α2-adrenergic receptors). Methyldopa is a proagent and is metabolized (α-Methylepinephrine) in the central nervous system[1][2].

IC50 & Target

α adrenergic receptor

 

体内研究
(In Vivo)

Methyldopa (L-(-)-α-Methyldopa; 200 mg/kg; i.p.) decreases the hyperglycemic response in the first 2 hr after Dieldrin treatment[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 60-day-old male rats[2]
Dosage: 200 mg/kg
Administration: I.p.
Result: Decreased the plasma concentration of glucose in Dieldrin-exposed rats by 24% during the 30 min following its administration.

Clinical Trial

分子量

211.21

Formula

C10H13NO4
CAS 号

555-30-6
性状

固体

颜色

White to off-white

中文名称

甲基多巴； 卡比多巴EP杂质A
结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 植物
  • 七叶树科
  • 欧洲七叶树
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
Data Sheet (532 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Sweet CS. New centrally acting antihypertensive drugs related to methyldopa and clonidine. Hypertension. 1984;6(5 Pt 2):II51-II56.  [Content Brief]

    [2]. Fox GR, et al. The effects of phenobarbital, atropine, L-alpha-methyldopa, and DL-propranolol on dieldrin-induced hyperglycemia in the adult rat. Toxicol Appl Pharmacol. 1985;78(3):342-350.  [Content Brief]

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