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3′-Sialyllactose (Synonyms: 3′-SL)
3′-Sialyllactose (3′-SL) 是一种益生元,具有维持免疫稳态,发挥抗炎和抗关节炎的作用。3′-Sialyllactose 是毒性等级最低的普通碳水化合物,可用于炎症的研究。
3′-Sialyllactose Chemical Structure
CAS No. : 35890-38-1
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3′-Sialyllactose 的其他形式现货产品:
生物活性 |
3′-Sialyllactose (3′-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3′-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation[1][2][3]. |
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体外研究 (In Vitro) |
3′-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1]. 3′-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1]. 3′-Sialyllactose (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation[3]. 3′-Sialyllactose (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis[1]
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体内研究 (In Vivo) |
3′-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1]. 3′-Sialyllactose (500, 1000 and 2000 mg/kg; orally administration; once) induces no micronuclei in the bone marrow cells of mice[3]. 3′-Sialyllactose (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3]. 3′-Sialyllactose shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
633.55 |
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Formula |
C23H39NO19 |
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CAS 号 |
35890-38-1 |
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结构分类 |
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初始来源 |
Human milk |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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纯度 & 产品资料 |
Data Sheet (539 KB) 产品使用指南 (1538 KB)
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参考文献 |
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