3′-Sialyllactose (Synonyms: 3′-SL)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
3′-Sialyllactose  (Synonyms: 3′-SL)

3′-Sialyllactose (3′-SL) 是一种益生元，具有维持免疫稳态，发挥抗炎和抗关节炎的作用。3′-Sialyllactose 是毒性等级最低的普通碳水化合物，可用于炎症的研究。

3

3′-Sialyllactose Chemical Structure

CAS No. : 35890-38-1

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3′-Sialyllactose 的其他形式现货产品:

3′-Sialyllactose sodium

3′-Sialyllactose 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

3′-Sialyllactose (3′-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3′-Sialyllactose is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation[1][2][3].

体外研究
(In Vitro)

3′-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].
3′-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1].
3′-Sialyllactose (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation[3].
3′-Sialyllactose (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

3′-Sialyllactose 相关抗体:

Western Blot Analysis[1]

Cell Line: Chondrocytes
Concentration: 0, 50, 100 and 250 μM
Incubation Time: 24-36 hours
Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3, Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes.

体内研究
(In Vivo)

3′-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1].
3′-Sialyllactose (500, 1000 and 2000 mg/kg; orally administration; once) induces no micronuclei in the bone marrow cells of mice[3].
3′-Sialyllactose (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3].
3′-Sialyllactose shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1]
Dosage: 10, 50 and 100 mg/kg
Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks
Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression.

分子量

633.55

Formula

C23H39NO19
CAS 号

35890-38-1
结构分类
  • Others
初始来源
  • 动物

Human milk
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (539 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Jeon J, et al. 3′-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66.  [Content Brief]

    [2]. Kang LJ, et al. 3′-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603.  [Content Brief]

    [3]. Kim D, et al. Toxicological evaluation of 3′-sialyllactose sodium salt. Regul Toxicol Pharmacol. 2018 Apr;94:83-90.  [Content Brief]

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