Xantocillin (Synonyms: 黄青霉素; Xanthocillin X)

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上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Xantocillin  (Synonyms: 黄青霉素; Xanthocillin X)

Xantocillin (Xanthocillin X) 是从青霉中提取的一种海洋药剂，通过抑制 MEK/ERK 途径诱导自噬。

Xantocillin (Synonyms: 黄青霉素; Xanthocillin X)

Xantocillin Chemical Structure

CAS No. : 580-74-5

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生物活性

Xantocillin (Xanthocillin X) is a marine agent extracted from Penicillium commune, induces autophagy through inhibition of the MEK/ERK pathway[1].

体外研究
(In Vitro)

Xantocillin (SD118-xanthocillin X (1)) (6.9-55.56 µM; 48 hours) has a significant inhibitory effect on the proliferation of HepG2 cells with an IC50 of 22.88 ± 4.76 µM[1].
Xantocillin (SD118-xanthocillin X (1)) (24.3 µM; 12-48 hours) increases the expression of the autophagy-related genes, LC3, and Beclin 1[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Xantocillin 相关抗体:

Cell Proliferation Assay[1]

Cell Line: HepG2 cells
Concentration: 6.9 µM, 13.89 µM, 27.78 µM, 55.56 µM
Incubation Time: 48 hours
Result: A concentration-dependent inhibitory effect on cellular growth in the HepG2 cells with the IC50 of 22.88 ± 4.76 µM.

Western Blot Analysis[1]

Cell Line: HepG2 cells
Concentration: 24.3 µM
Incubation Time: 12 hours, 24 hours, 48 hours
Result: Increased the expression of the autophagy-related genes, LC3, and Beclin 1.

分子量

288.30

Formula

C18H12N2O2
CAS 号

580-74-5
中文名称

黄青霉素
结构分类
  • Phenols
  • Polyphenols
初始来源
  • 海洋天然产物
  • 海洋微生物
  • 微生物

Marine-Associated Fungus Penicillium sp. ZZ1750
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (524 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Zhao Y,et al. SD118-xanthocillin X (1), a novel marine agent extracted from Penicillium commune, induces autophagy through the inhibition of the MEK/ERK pathway. Mar Drugs. 2012 Jun;10(6):1345-59.  [Content Brief]

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