Mevalonic acid (Synonyms: MVA)

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Mevalonic acid  (Synonyms: MVA)

Mevalonic acid (MVA) 是甲羟戊酸途径 (mevalonate pathway) 的前体物质，对细胞生长和增殖至关重要。Mevalonic acid 在体外能有效抑制 Simvastatin (HY-17502) 诱导的 C2C12 细胞活力下降，可用于肌病和心力衰竭的研究。

Mevalonic acid (Synonyms: MVA)

Mevalonic acid Chemical Structure

CAS No. : 150-97-0

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Mevalonic acid 相关产品

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生物活性

Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure[1][2].

体外研究
(In Vitro)

Mevalonic acid (80, 90, 100, 110 µM; 72 h) shows prevention of simvastatin-induced loss of viability of C2C12myotube cells in vitro[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Mevalonic acid 相关抗体:

Cell Viability Assay[1]

Cell Line: C2C12 cells (simvastatin-induced)
Concentration: 80, 90, 100, 110 µM
Incubation Time: 72 h
Result: Showed no decline in cell viability.

Clinical Trial

分子量

148.16

Formula

C6H12O4
CAS 号

150-97-0
性状

固体

颜色

White to off-white

结构分类
  • Ketones, Aldehydes, Acids
初始来源
  • 内源性代谢物
  • 疾病标志物
  • 内分泌疾病
  • 内源性代谢物
  • 疾病标志物
  • 神经系统疾病
  • 内源性代谢物
  • 疾病标志物
  • 免疫系统疾病
  • 内源性代谢物
  • 人肠道微生物代谢物
  • 微生物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

Data Sheet (531 KB) SDS (251 KB)

COA (259 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Moschetti A, et al. Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes. Nanomedicine. 2021 Oct;37:102439.  [Content Brief]

    [2]. Soma MR, et al. Cholesterol and mevalonic acid modulation in cell metabolism and multiplication. Toxicol Lett. 1992 Dec;64-65 Spec No:1-15.  [Content Brief]

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