Enniatin B1 (Synonyms: 恩镰孢菌素 B1)

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Enniatin B1  (Synonyms: 恩镰孢菌素 B1) 纯度: ≥97.0%

Enniatin B1 是一种镰刀菌毒素。在大鼠肝微粒体酶实验中，Enniatin B1 抑制酰基辅酶 A：胆固醇酰基转移酶 (ACAT) 活性，IC50 为 73 μM。Enniatin B1 能透过血脑屏障。Enniatin B1 降低 ERK (p44/p42) 活化。Enniatin B1 抑制 TNF-α 诱导的 NF-κB激活。

Enniatin B1 (Synonyms: 恩镰孢菌素 B1)

Enniatin B1 Chemical Structure

CAS No. : 19914-20-6

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生物活性

Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 73 μM in an enzyme assay using rat liver microsomes[1]. Enniatin B1 crosss the blood-brain barrier[2]. Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation[3].

IC50 & Target[1][2]

ACAT

 

ERK

 

NF-κB

 

体外研究
(In Vitro)

CCF-STTG1 cells are sensitive to Enniatin B1 (IC50=4.4 μM)[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Enniatin B1 相关抗体:
分子量

653.85

Formula

C34H59N3O9
CAS 号

19914-20-6
性状

固体

颜色

White to off-white

中文名称

镰孢菌素 B1；恩镰孢菌素 B1
结构分类
  • Alkaloids
初始来源
  • 微生物

Fusarium mycotoxins
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: ≥97.0%

Data Sheet (538 KB) SDS (251 KB)

COA (179 KB) HNMR (269 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Tomoda H, et al. Inhibition of acyl-CoA: cholesterol acyltransferase activity by cyclodepsipeptide antibiotics. J Antibiot (Tokyo). 1992 Oct;45(10):1626-32.  [Content Brief]

    [2]. Krug I, et al. Transport of enniatin B and enniatin B1 across the blood-brain barrier and hints for neurotoxic effects in cerebral cells. PLoS One. 2018 May 16;13(5):e0197406.  [Content Brief]

    [3]. Wätjen W, et al. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation. Mol Nutr Food Res. 2009 Apr;53(4):431-40.  [Content Brief]

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