上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Humulone (Synonyms: 律草酮; α-Lupulic acid) 纯度: 99.33%
Humulone (α-Lupulic acid) 是一种异戊二烯化间苯三酚衍生物,是一种有效的环氧合酶 2 (COX-2) 抑制剂。Humulone 在低微摩尔浓度下作为 GABAA 受体的正调节剂。Humulone 是一种骨吸收抑制剂。Humulone 具有抗氧化、抗血管生成和诱导细胞凋亡的特性。
Humulone Chemical Structure
CAS No. : 26472-41-3
规格 | 价格 | 是否有货 | 数量 |
---|---|---|---|
1 mg | ¥2640 | In-stock | |
5 mg | ¥6600 | In-stock | |
10 mg | 询价 | ||
50 mg | 询价 |
* Please select Quantity before adding items.
Humulone 相关产品
•相关化合物库:
- Natural Product Library Plus
- Bioactive Compound Library Plus
- Apoptosis Compound Library
- Immunology/Inflammation Compound Library
- Membrane Transporter/Ion Channel Compound Library
- Neuronal Signaling Compound Library
- Natural Product Library
- Anti-Aging Compound Library
- Antioxidant Compound Library
- Anti-Cardiovascular Disease Compound Library
- Pyroptosis Compound Library
- Neurotransmitter Receptor Compound Library
- Anti-Alzheimer’s Disease Compound Library
- Neuroprotective Compound Library
- Anti-Pancreatic Cancer Compound Library
- Anti-Parkinson’s Disease Compound Library
- Neurodegenerative Disease-related Compound Library
- Anti-Colorectal Cancer Compound Library
- Antidepressant Compound Library
- Plant-Sourced Natural Product Library
- GABA Receptor Compound Library
- Anti-Prostate Cancer Compound Library
- Membrane Protein-targeted Compound Library
- Membrane Receptor-targeted Compound Library
- Cysteine Targeted Covalent Library
- Cell Death Library
- Ion Channel Compound Library
- Multi-Target Compound Library
- Radioprotector Library
生物活性 |
Humulone (α-Lupulic acid), a prenylated phloroglucinol derivative, is a potent cyclooxygenase-2 (COX-2) inhibitor. Humulone acts as a positive modulator of GABAA receptor at low micromolar concentrations. Humulone is an inhibitor of bone resorption. Humulone possesses antioxidant, anti-angiogenic and apoptosis-inducing properties[1][2][3]. |
||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
IC50 & Target[1][2][3] |
|
||||||||||||
体外研究 (In Vitro) |
Humulone (0.1, 1, 10, 100, 1000, 10000 nM; for 12 h) with with 10 ng/ml TNFα dose-dependently decreases the amount of released PGE2 with an IC50 of about 30 nM in MC3T3-E1 cells. Humulone reduces cyclooxygenase activity of the TNFK-treated cells[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
||||||||||||
体内研究 (In Vivo) |
Humulone (10 or 20 mg/kg; IP; single dose) shortens sleep onset and increases the duration of sleep induced by pentobarbital and decreases the spontaneous locomotion in open field at 20 mg/kg[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
|
||||||||||||
分子量 |
362.46 |
||||||||||||
Formula |
C21H30O5 |
||||||||||||
CAS 号 |
26472-41-3 |
||||||||||||
性状 |
油状物 |
||||||||||||
颜色 |
Light yellow to yellow |
||||||||||||
中文名称 |
律草酮 |
||||||||||||
结构分类 |
|
||||||||||||
初始来源 |
|
||||||||||||
运输条件 |
Room temperature in continental US; may vary elsewhere. |
||||||||||||
储存方式 |
-20°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
||||||||||||
溶解性数据 |
In Vitro:
DMSO 中的溶解度 : 50 mg/mL (137.95 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO) 配制储备液
查看完整储备液配制表
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2
动物溶解方案计算器
请输入动物实验的基本信息:
给药剂量 mg/kg 动物的平均体重 g 每只动物的给药体积 μL 动物数量 只 由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
|
||||||||||||
纯度 & 产品资料 |
纯度: 99.33%
Data Sheet (607 KB) SDS (252 KB)
COA (264 KB) HNMR (266 KB) LCMS (264 KB) 产品使用指南 (1538 KB) |
||||||||||||
参考文献 |
|
所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务