Hamaudol

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Hamaudol  纯度: 99.59%

Hamaudol 是从 Saposhnikovia divaricata 中分离出的一种色酮。Hamaudol 对环加氧酶 (COX)-1 和 COX-2 的活性具有明显的抑制能力，其 IC50 值分别为 0.30、0.57 mM，并且具有有效抗炎作用，可用于缓解疼痛的研究。

Hamaudol

Hamaudol Chemical Structure

CAS No. : 735-46-6

规格 价格 是否有货 数量
1 mg ￥1150 In-stock
5 mg ￥2900 In-stock
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生物活性

Hamaudol is a chromone isolated from Saposhnikovia divaricata. Hamaudol shows significant inhibitory activity on cyclooxygenase (COX)-1 and COX-2 activities with IC50 values of 0.30, 0.57 mM, respectively, and has potent analgesia and anti-inflammary effects[1][2].

IC50 & Target

COX-1

0.3 mM (IC50)

COX-2

0.57 mM (IC50)

体内研究
(In Vivo)

Hamaudol (Compound 7) increases the potency to exhibit a potent analgesia at doses of 1, 5 and 10 mg/kg in mice, although it do not show clear dose dependency[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

276.28

Formula

C15H16O5
CAS 号

735-46-6
性状

固体

颜色

White to off-white

结构分类
  • Phenols
  • Monophenols
  • Ketones, Aldehydes, Acids
初始来源
  • 植物
  • 菊科
  • Ophryosporus axilliflorus Hieron.
  • 植物
  • 伞形科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料

纯度: 99.59%

Data Sheet (531 KB) SDS (251 KB)

COA (265 KB) RP-HPLC (289 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Okuyama E, et al. Analgesic components of saposhnikovia root (Saposhnikovia divaricata). Chem Pharm Bull (Tokyo). 2001 Feb;49(2):154-60.  [Content Brief]

    [2]. Mingshan Zheng, et al. The Constituents Isolated from Peucedanum japonicum Thunb. and their Cyclooxygenase (COX) Inhibitory Activity. Korean Journal of Medicinal Crop Science, 2005, 13(2).

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