Kauran-16,17-diol (Synonyms: ent-Kauran-16β,17-diol)

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Kauran-16,17-diol  (Synonyms: ent-Kauran-16β,17-diol) 纯度: 99.51%

Kauran-16,17-diol (ent-Kauran-16β,17-diol) 是一个天然的二萜化合物，具有抗肿瘤诱导凋亡的活性。其抑制 LPS 诱导的RAW 264.7 细胞产生 NO 的 IC50 值为17 μM。

Kauran-16,17-diol (Synonyms: ent-Kauran-16β,17-diol)

Kauran-16,17-diol Chemical Structure

CAS No. : 16836-31-0

规格 价格 是否有货 数量
1 mg ￥1650 In-stock
5 mg ￥3300 In-stock
10 mg ￥5115 In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Kauran-16,17-diol 相关产品

•相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • Immunology/Inflammation Compound Library
  • Natural Product Library
  • Anti-Cancer Compound Library
  • Terpenoids Library
  • Traditional Chinese Medicine Active Compound Library
  • Anti-Cancer Natural Product Library
  • Anti-inflammatory Traditional Chinese Medicine Active Compound Library
  • Plant-Sourced Natural Product Library
  • Cell Death Library
  • Macrophage Related Compound Library

•同靶点产品:

•同靶点蛋白产品:

生物活性

Kauran-16,17-diol (ent-Kauran-16β,17-diol), a natural diterpene, posseses anti-tumor and inducing-apoptosis activity, with a IC50 of 17 μM on inhibiting NO production in LPS-stimulated RAW 264.7 macrophages[1][2].

体外研究
(In Vitro)

Kauran-16,17-diol (ent-Kauran-16β,17-diol) down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Kauran-16,17-diol 相关抗体:
分子量

306.48

Formula

C20H34O2
CAS 号

16836-31-0
性状

固体

颜色

White to off-white

中文名称

对映-贝壳杉-16β,17-二醇
结构分类
  • Terpenoids
  • Diterpenoids
初始来源
  • 植物
  • 百合科
  • 川贝母
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 99.51%

Data Sheet (516 KB) SDS (393 KB)

COA (196 KB) HNMR (147 KB) CNMR (123 KB) RP-HPLC (92 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Alvaro Morales, et al. The natural diterpene ent-16β-17α-dihydroxykaurane down-regulates Bcl-2 by disruption of the Ap-2α/Rb transcription activating complex and induces E2F1 up-regulation in MCF-7 cells. Apoptosis. 2011 Dec;16(12):1245-52.  [Content Brief]

    [2]. Nguyen Xuan Nhiem, et al. New ent-kauranes from the fruits of Annona glabra and their inhibitory nitric oxide production in LPS-stimulated RAW264.7 macrophages. Bioorg Med Chem Lett. 2015 Jan 15;25(2):254-8.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务