Angoline hydrochloride

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Angoline hydrochloride 

Angoline hydrochloride 是一种有效的、选择性的 IL6/STAT3 信号通路抑制剂，IC50 为 11.56 μM。Angoline hydrochloride 抑制 STAT3 磷酸化及其靶基因表达，并抑制癌细胞增殖。

Angoline hydrochloride

Angoline hydrochloride Chemical Structure

CAS No. : 1071676-04-4

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Angoline hydrochloride 的其他形式现货产品:

Angoline

Angoline hydrochloride 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Angoline hydrochloride is a potent and selective IL6/STAT3 signaling pathway inhibitor with an IC50 of 11.56 μM. Angoline hydrochloride inhibits STAT3 phosphorylation and its target gene expression, and inhibits cancer cell proliferation[1].

IC50 & Target

IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)[1]
体外研究
(In Vitro)

Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC50 values of 11.56, ＞100 and ＞100 μM, respectively[1].
Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3[1].
Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Angoline hydrochloride 相关抗体:

Western Blot Analysis[1]

Cell Line: HepG2/STAT3 cell lines
Concentration: 0, 1, 10, 30 and 100 μM
Incubation Time: 2 hours
Result: Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells.

Western Blot Analysis[1]

Cell Line: MDA-MB-231, H4 and HepG2 cell lines
Concentration: 0-100 μM
Incubation Time: 72 hours
Result: Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC50 values of 3.32, 4.72 and 3.14 μM, respectively.

分子量

415.87

Formula

C22H22ClNO5
CAS 号

1071676-04-4
结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
初始来源
  • 植物
  • 罂粟科
  • 博落回
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (532 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Jiawei Liu, et al. Angoline: a selective IL-6/STAT3 signaling pathway inhibitor isolated from Zanthoxylum nitidum. Phytomedicine. Jul-Aug 2014;21(8-9):1088-91.  [Content Brief]

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