Zeaxanthin dipalmitate (Synonyms: Physalien)

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Zeaxanthin dipalmitate  (Synonyms: Physalien) 纯度: ≥95.0%

Zeaxanthin dipalmitate (Physalien) 是一种枸杞衍生的类胡萝卜素，具有抗炎和抗氧化应激作用。Zeaxanthin dipalmitate 与 p2X7 受体 (Kd=81.2 nM) 和脂联素受体 1 (AdipoR1; Kd=533 nM) 以正剂量依赖性方式直接相互作用。Zeaxanthin dipalmitate 恢复乙醇中毒抑制的线粒体自噬 (autophagy) 功能。Zeaxanthin dipalmitate 可用于酒精性脂肪肝 (AFLD)、色素性视网膜炎 (RP) 的研究。

Zeaxanthin dipalmitate (Synonyms: Physalien)

Zeaxanthin dipalmitate Chemical Structure

CAS No. : 144-67-2

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生物活性

Zeaxanthin dipalmitate (Physalien) is a wolfberry-derived carotenoid, has anti-inflammatory and anti-oxidative stress effects. Zeaxanthin dipalmitate directly interact with p2X7 receptor (Kd=81.2 nM) and adiponectin receptor 1 (AdipoR1; Kd=533 nM) in a positive dose-dependent manner. Zeaxanthin dipalmitate restores mitochondrial autophagy functions suppressed by ethanol intoxication. Zeaxanthin dipalmitate can be used in the research of alcoholic fatty liver disease (AFLD) and retinitis pigmentosa (RP)[1][2].

IC50 & Target

p2X7/AdipoR1 receptor[1]
体外研究
(In Vitro)

Zeaxanthin dipalmitate (1 µM; 2 h) totally or partially reverses the down-regulation of Atg5, beclin-1, and LC3A/B by ethanol (250 mM), and the up-regulation of p62 by ethanol in BRL-3A cells[1].
Zeaxanthin dipalmitate (1 µM; 2 h) partially recovers the ethanol-suppressed LC3B in BRL-3A cells[1].
Zeaxanthin dipalmitate (1 µM; 2 h) partially recovers the ethanol-suppressed cell viability and ethanol-induced aspase-3/7 activity of BRL-3A cells[1].
Zeaxanthin dipalmitate (1 µM; 2 h) recovers the ethanol-induced inhibition of mitophagy in BRL-3A cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Zeaxanthin dipalmitate 相关抗体:
体内研究
(In Vivo)

Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) reduces the serum ALT and AST levels increased by long-term ethanol challenge in at AFLD Model[1].
Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) effectively attenuates the histological injury[1].
Zeaxanthin dipalmitate (10 mg/kg; p.o.; daily for 2 weeks) attenuates the AFLD-induced hepatic apoptosis (reveal by caspase-3/7 activity) and inflammation (TNF-α) in rat[1].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the visual behavior of rd10 mice and delays the degeneration of retinal photoreceptors[2].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) improves the light responses of photoreceptors, bipolar cells and retinal ganglion cells[2].
Zeaxanthin dipalmitate (approximately 4 μM; intravitreal injection for once) reduces the expression of genes that are involved in inflammation, apoptosis and oxidative stress in rd10 mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1045.69

Formula

C72H116O4
CAS 号

144-67-2
性状

固体

颜色

Brown to reddish brown

结构分类
  • Terpenoids
  • Diterpenoids
初始来源
  • 植物
  • 茄科
  • 枸杞
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

Ethanol 中的溶解度 : 1 mg/mL (0.96 mM; 超声加热助溶)

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纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (593 KB) SDS (0 KB)

COA (189 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Gao H, et al. Wolfberry-Derived Zeaxanthin Dipalmitate Attenuates Ethanol-Induced Hepatic Damage. Mol Nutr Food Res. 2019 Jun;63(11):e1801339.  [Content Brief]

    [2]. Liu F, et al. Wolfberry-derived zeaxanthin dipalmitate delays retinal degeneration in a mouse model of retinitis pigmentosa through modulating STAT3, CCL2 and MAPK pathways. J Neurochem. 2021 Sep;158(5):1131-1150.  [Content Brief]

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