Verminoside

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Verminoside  纯度: ≥98.0%

Verminoside 是从 Kigelia africana 分离出的一种环烯醚萜，具有抗炎和显着的抗氧化活性，其自由基清除活性为 2.5 μg/mL。Verminoside 对人淋巴细胞的遗传毒性与 PARP-1 和 p53 蛋白水平升高有关。

Verminoside

Verminoside Chemical Structure

CAS No. : 50932-19-9

规格 价格 是否有货 数量
500 μg ￥4900 In-stock

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Verminoside 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

Verminoside is an iridoid isolated from Kigelia africana, exhibits anti-inflammatory and remarkable antioxidant activity with a radical-scavenging activity of 2.5 μg/mL. The genotoxicity of Verminoside on human lymphocytes is associated with elevated levels of PARP-1 and p53 proteins[1][2][3].

IC50 & Target[2]

PARP-1

 

体外研究
(In Vitro)

Verminoside (Compound 1; 0.01-1 mM; 25 hours; J774.A1 macrophages) treatment shows significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Verminoside 相关抗体:

Western Blot Analysis[1]

Cell Line: J774.A1 macrophages
Concentration: 0.01 mM, 0.1 mM or 1 mM
Incubation Time: 25 hours
Result: Showed significant and concentration-related inhibition of iNOS expression at 0.1 mM and 1 mM in LPS-stimulated J774.A1 macrophages.

分子量

524.47

Formula

C24H28O13
CAS 号

50932-19-9
性状

固体

颜色

Light brown to brown

结构分类
  • Terpenoids
  • Iridoids
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 其他科
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

Data Sheet (534 KB) SDS (251 KB)

COA (176 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Picerno P, et al. Anti-inflammatory activity of verminoside from Kigelia africana and evaluation of cutaneous irritation in cell cultures and reconstituted human epidermis. J Nat Prod. 2005 Nov;68(11):1610-4.  [Content Brief]

    [2]. Boniface PK, et al. RP-HPLC-DAD method for the identification of two potential antioxidant agents namely verminoside and 1-O-(E)-caffeoyl-β-gentiobiose from Spathodea campanulata leaves. Nat Prod Res. 2015;29(7):676-80.  [Content Brief]

    [3]. Santoro A, et al. Verminoside- and verbascoside-induced genotoxicity on human lymphocytes: involvement of PARP-1 and p53 proteins. Toxicol Lett. 2008 May 5;178(2):71-6.  [Content Brief]

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