Taccalonolide B (Synonyms: 根薯酮内酯B)

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Taccalonolide B  (Synonyms: 根薯酮内酯B) 纯度: 98.59%

Taccalonolide B 是从 Tacca plantaginea 中分离得到的微管稳定剂，具有抗肿瘤活性。Taccalonolide B 在体外对过表达 p 糖蛋白 (Pgp) 和多药耐药蛋白 (MRP7) 的细胞系具有显著的抑制作用。Taccalonolide B 抑制 SK-OV-3 细胞生长的 IC50 值为 208 nM。

Taccalonolide B (Synonyms: 根薯酮内酯B)

Taccalonolide B Chemical Structure

CAS No. : 108885-69-4

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10 mg ￥3000 In-stock
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Taccalonolide B 相关产品

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生物活性

Taccalonolide B is microtubule stabilizer isolated from Tacca plantaginea, with antitumor activity. Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM[1][2].

IC50 & Target

microtubule[2]
分子量

660.71

Formula

C34H44O13
CAS 号

108885-69-4
性状

固体

颜色

White to off-white

中文名称

根薯酮内酯B
结构分类
  • Steroids
初始来源
  • 植物
  • 蒟蒻薯科
  • 裂果薯
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

纯度 & 产品资料

纯度: 98.59%

Data Sheet (536 KB) SDS (251 KB)

COA (181 KB) HNMR (229 KB) RP-HPLC (237 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. LiangChen Zhong, et al. Steroidal bitter principles from tacca plantaginea structures of taccalonolide A and B. Tetrahedron Letters. 1987, 28(15): 1673-1675.

    [2]. Risinger AL, et al. The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms. Cancer Res. 2008 Nov 1;68(21):8881-8.  [Content Brief]

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