Violacein

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Violacein  纯度: 84.69%

Violacein 是微生物的次级代谢物，具有较强的抗癌活性和低副作用。Violacein 具有抗氧化活性。凋亡诱导剂。

Violacein

Violacein Chemical Structure

CAS No. : 548-54-9

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1 mg ￥5850 询问价格 & 货期

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Violacein 相关产品

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生物活性

Violacein, a secondary metabolite produced by several microorganisms, possesses potent anticancer and low side effects. Violacein possesses antioxidant properties. Apoptosis inducer[1][2].

IC50 & Target

Microbial Metabolite

 

体外研究
(In Vitro)

Violacein (0.25-3 µM; 24h; HCT116 and HT29 cells) possesses anticancer activity in both 2D and 3D cell models[1].
Violacein decreases RTKs expression and disturbs signaling pathways in CRC cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Violacein 相关抗体:

Cell Viability Assay[1].

Cell Line: HCT116 and HT29 (1.8 × 104 cells/well-100 µL) cells.
Concentration: 0.25, 0.5, 1.0, 1.5, 2.0, 2.5, and 3.0 µM.
Incubation Time: 24h.
Result: In the 2D culture model, the violacein treatment reduced the cell viability, since there was a decrease in formazan production in the HT29 and HCT116 cell lines. Moreover, HT29 was more sensitive to violacein, as evidenced by the IC50 value (0.6 μM) compared to HCT116 (1.2 μM).

分子量

343.34

Formula

C20H13N3O3
CAS 号

548-54-9
性状

固体

颜色

Brown to black

结构分类
  • Alkaloids
  • Indole Alkaloids
初始来源
  • 微生物

Chromobacterium violaceum
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 84.69%

Data Sheet (533 KB) SDS (0 KB)

COA (201 KB) HNMR (221 KB) RP-HPLC (407 KB) LCMS (645 KB)

产品使用指南 (1538 KB)

参考文献

  • [1]. Patricia F de Souza Oliveira, et al. Violacein negatively modulates the colorectal cancer survival and epithelial-mesenchymal transition. J Cell Biochem. 2022 Jul;123(7):1247-1258.  [Content Brief]

    [2]. Marlon Konzen, et al. Antioxidant properties of violacein: possible relation on its biological function. Bioorg Med Chem. 2006 Dec 15;14(24):8307-13.  [Content Brief]

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