CPUL1

发表于由

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
CPUL1 

CPUL1 是一种 TrxR 抑制剂，对 A549 细胞显示出增殖抑制和抗转移活性。CPUL1 通过抑制 TrxR1 酶活性来诱导 ROS 介导的 ERK/JNK 信号传导从而影响上皮-间质转化 (EMT)。CPUL1 与 α-Lipoic Acid (HY-N0492) 或 Dithiodipropionic acid (HY-W014395) 联合使用效果更好。

CPUL1

CPUL1 Chemical Structure

CAS No. : 2043660-80-4

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

CPUL1 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

CPUL1 is a TrxR inhibitor, which shows proliferation-inhibitory and anti-metastatic activity against A549 cells. CPUL1 influences EMT (epithelial-mesenchymal transition) via inducing ROS-mediated ERK/JNK signaling by inhibiting TrxR1 enzyme activity. CPUL1 in combination with α-Lipoic Acid (HY-N0492) or Dithiodipropionic acid (HY-W014395) is more effective[1].

体外研究
(In Vitro)

CPUL1 (2.5, 5, 10, 20, 40 μM; 48 h) inhibits A549 cell proliferation and (2, 4, 8 μM; 48 h) colony formation[1].
CPUL1 (4, 8 μM; 0, 24, 48 h) inhibits A549 cells migration and (2, 4, 8 μM; 48 h) invasion[1].
CPUL1 hinders EMT (epithelial-mesenchymal transition) progress and affects MAPK pathway in A549 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

CPUL1 相关抗体:

Cell Proliferation Assay[1]

Cell Line: A549 cells
Concentration: 2.5, 5, 10, 20, 40 μM
Incubation Time: 48 h
Result: Showed a dose-dependent cytotoxicity, with an IC50 value of 7.61 μM.

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 2, 4, 8 μM
Incubation Time: 48 h
Result: Significantly abolished the capacity of A5459 cells to form colonies at the dose-dependent concentration.

Cell Migration Assay [1]

Cell Line: A549 cells
Concentration: 4, 8 μM
Incubation Time: 0, 24, 48 h
Result: Inhibited the migration of A549 cells in a dose- and time-dependent manner.

分子量

434.28

Formula

C22H13Cl2N5O
CAS 号

2043660-80-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (538 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Ding Q, et al. A thioredoxin reductase 1 inhibitor pyrano [3,2-a] phenazine inhibits A549 cells proliferation and migration through the induction of reactive oxygen species production. Mol Biol Rep. 2022 Sep;49(9):8835-8845.  [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务