CMP-Sialic acid (Synonyms: CMP-Neu5Ac)

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CMP-Sialic acid  (Synonyms: CMP-Neu5Ac)

CMP-Sialic acid (CMP-Neu5Ac) 是 UDP-GlcNAc 2-epimerase 的变构抑制剂。CMP-Sialic acid 可为高尔基体唾液酸转移酶提供底物。CMP-Sialic acid 是唾液酸及其结合物的生物合成中的重要糖类核苷酸。

CMP-Sialic acid (Synonyms: CMP-Neu5Ac)

CMP-Sialic acid Chemical Structure

CAS No. : 3063-71-6

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CMP-Sialic acid 的其他形式现货产品:

CMP-Sialic acid sodium salt

CMP-Sialic acid 相关产品

•同靶点产品:

•同靶点蛋白产品:

生物活性

CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates[1].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

CMP-Sialic acid (22.5 μM, 45 min) 可用作 CMAH 底物来检测血小板裂解物中 Neu5Gc 的形成[1]。

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

CMP-Sialic acid 相关抗体:
分子量

614.45

Formula

C20H31N4O16P
CAS 号

3063-71-6
结构分类
  • Others
初始来源
  • 内源性代谢物
  • 人肠道微生物代谢物
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (531 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Münster AK, et al. Mammalian cytidine 5′-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5.  [Content Brief]

    [2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

    [3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795.  [Content Brief]

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