Dipsacoside B (Synonyms: 川续断皂苷乙；川续断皂苷 B)

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Dipsacoside B (Synonyms: 川续断皂苷乙；川续断皂苷 B) 纯度: 99.17%

Dipsacoside B 是一种主要的具有生物活性的皂素，可用作标志物。

Dipsacoside B Chemical Structure

CAS No. : 33289-85-9

规格	价格	是否有货
5 mg	￥550	In-stock
10 mg	￥950	In-stock
50 mg	￥2400	In-stock
100 mg		询价
200 mg		询价

* Please select Quantity before adding items.

Dipsacoside B 相关产品

•相关化合物库:

Natural Product Library Plus
Bioactive Compound Library Plus
Immunology/Inflammation Compound Library
Natural Product Library
Glycoside Compound Library
Medicine Food Homology Compound Library
Terpenoids Library
Traditional Chinese Medicine Active Compound Library
Anti-inflammatory Traditional Chinese Medicine Active Compound Library
Plant-Sourced Natural Product Library
Heterocyclic Compound Library

•同靶点产品:

•同靶点蛋白产品:

生物活性

Dipsacoside B is a major bioactive saponin, which can be used as a marker.

体内研究
(In Vivo)

A liquid chromatography-electrospray ionization-mass spectrometry method has been developed and validated for identification and quantification of four major bioactive saponins in rat plasma after oral administration of extraction of saponins from Flos Lonicerae, i.e., Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B. The retention time of Macranthoidin B, Macranthoidin A, Dipsacoside B, Macranthoside B and IS are 10.65, 12.11, 13.81, 23.31 and 5.47 min, respectively^[1]. Taking Macranthoidins A, B, Dipsacoside B (saponins), sweroside (iridoids), and luteolin-7-O-d-glucoside (flavonoids) as markers, a method of ultra high performance liquid chromatography with triple quadrupole mass spectrometry is employed to determine their amounts in Lonicerae Flos, Lonicerae Japonicae Flos, and Lonicerae Japonicae Flos preparations^[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1075.24

Formula

C₅₃H₈₆O₂₂

CAS 号

33289-85-9

性状

固体

颜色

White to off-white

中文名称

川续断皂苷乙；川续断皂苷 B

结构分类

Terpenoids
Triterpenes

初始来源

植物
川续断科
川续断

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO 中的溶解度 : 100 mg/mL (93.00 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.9300 mL	4.6501 mL	9.3002 mL
5 mM	0.1860 mL	0.9300 mL	1.8600 mL
10 mM	0.0930 mL	0.4650 mL	0.9300 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (2.33 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水定容至 1 mL。

生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
方案二

请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (2.33 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

20% SBE-β-CD in Saline 的配制（4°C，储存一周）：2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
方案三

请依序添加每种溶剂： 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (2.33 mM); 澄清溶液

此方案可获得 ≥ 2.5 mg/mL（饱和度未知）的澄清溶液，此方案实验周期在半个月以上的动物实验酌情使用。

以 1 mL 工作液为例，取 100 μL 25.0 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

请输入您的动物体内配方组成：

DMSO +

Tween-80 +

Saline

如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。

方案所需 助溶剂 包括：DMSO，，均可在 Shanghai Jinpan Biotech Co Ltd 网站选购。，Tween 80，均可在 Shanghai Jinpan Biotech Co Ltd 网站选购。

计算结果

工作液所需浓度 : mg/mL

储备液配制方法 : mg 药物溶于 μL DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

免费服务热线：021-50837765
E-mail：sales@jinpanbio.com
技术支持电话：021-50837765
技术支持邮箱：sales@jinpanbio.com

动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。

连续给药周期超过半月以上，请谨慎选择该方案。

请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热（超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。

纯度 & 产品资料

纯度: 99.17%

选择批次：

Data Sheet (625 KB) SDS (393 KB)

COA (284 KB) HNMR (356 KB) LCMS (263 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Chen CY, et al. Liquid chromatography-mass spectrometry analysis of macranthoidin B, macranthoidin A, Dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3) [Content Brief]

[2]. Zhang X, et al. Rapid quantitative analysis of adulterant Lonicera species in preparations of Lonicerae Japonicae Flos. J Sep Sci. 2015 Dec;38(23):4014-20. [Content Brief]

Animal Administration ^[1]	Mice^[1] Sprague-Dawley rats (220-250 g) are used. To calculate the administered dose of Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B, their contents in saponins extraction are quantitatively determined. One hundred milligrams of the dry powder is suspended in 100 mL 50% methanol (v/v), ultrasonically extracted for 40 min, and then cooled at room temperature; 50% methanol is added to compensate for the lost weight. Finally, 5 μL of this solution is injected into the HPLC system for analysis after filtration through a 0.45 μm membrane. The contents of Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B are found as 36.7, 6.59, 23.3 and 0.506 g/100 g extraction, respectively. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Chen CY, et al. Liquid chromatography-mass spectrometry analysis of macranthoidin B, macranthoidin A, Dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3) [Content Brief] [2]. Zhang X, et al. Rapid quantitative analysis of adulterant Lonicera species in preparations of Lonicerae Japonicae Flos. J Sep Sci. 2015 Dec;38(23):4014-20. [Content Brief]

Animal Administration
^[1]

Mice^[1]
Sprague-Dawley rats (220-250 g) are used. To calculate the administered dose of Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B, their contents in saponins extraction are quantitatively determined. One hundred milligrams of the dry powder is suspended in 100 mL 50% methanol (v/v), ultrasonically extracted for 40 min, and then cooled at room temperature; 50% methanol is added to compensate for the lost weight. Finally, 5 μL of this solution is injected into the HPLC system for analysis after filtration through a 0.45 μm membrane. The contents of Macranthoidin B, Macranthoidin A, Dipsacoside B, and Macranthoside B are found as 36.7, 6.59, 23.3 and 0.506 g/100 g extraction, respectively.

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Chen CY, et al. Liquid chromatography-mass spectrometry analysis of macranthoidin B, macranthoidin A, Dipsacoside B, and macranthoside B in rat plasma for the pharmacokinetic investigation. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Jan 15;877(3) [Content Brief]

[2]. Zhang X, et al. Rapid quantitative analysis of adulterant Lonicera species in preparations of Lonicerae Japonicae Flos. J Sep Sci. 2015 Dec;38(23):4014-20. [Content Brief]

所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Dipsacoside B 相关产品

•相关化合物库:

•同靶点产品:

•同靶点蛋白产品:

摩尔计算器

稀释计算器