Coformycin

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Coformycin 

Coformycin 是一种核苷类抗生素，是腺苷脱氨酶 (adenosine deaminase , ADA) 的抑制剂。Coformycin 具有抗肿瘤和抗菌活性。

Coformycin

Coformycin Chemical Structure

CAS No. : 11033-22-0

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生物活性

Coformycin, a nucleoside antibiotic, is a potent inhibitor of adenosine deaminase (ADA) from Streptomyces species. Coformycin possesses anti-tumor and anti-bacterial activity[1][2].

体内研究
(In Vivo)

Coformycin (0.2 mg/kg, ip daily) inhibits adenosine deaminase activity for various tissues, including brain, heart, kidney, liver, etc[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Swiss-Webster mice[2].
Dosage: 0.2 mg/kg.
Administration: IP daily.
Result: Inhibited adenosine deaminase activity for various tissues.

分子量

284.27

Formula

C11H16N4O5
CAS 号

11033-22-0
结构分类
  • Antibiotics
  • Disease Research
  • Antibacterial
  • Antibiotics
  • Disease Research
  • Anticancer
  • Antibiotics
  • Other Antibiotics
初始来源
  • 微生物

Nocardia interforma and Streptomyces kaniharaensis SF-557
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
Data Sheet (531 KB) 产品使用指南 (1538 KB)

参考文献

  • [1]. Coformycin.

    [2]. Lukey T, et al. S-adenosylhomocysteine hydrolase activity, deoxyadenosine triphosphate accumulation, and competence of thymocyte and spleen leucocyte response to mitogens in coformycin-treated mice. Biochem Pharmacol. 1983 Apr 15;32(8):1399-406.  [Content Brief]

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