Tubulysin I (Synonyms: 微管蛋白抑制剂 I)

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Tubulysin I  (Synonyms: 微管蛋白抑制剂 I)

Tubulysin I 是具有高细胞毒性的抗微管毒素 (anti-microtubule toxins),作为 ADC 细胞毒素 (ADC Cytotoxin) 合成 ADC。Tubulysin I 能够从粘细菌 Archangium geophyraAngiococcus disciformis 中分离得到。Tubulysin I 在哺乳动物细胞中显示出极其有效的细胞毒活性,包括多药耐药细胞系,IC50 值在较低的纳摩尔范围内。Tubulysin I 可抑制微管蛋白 (Microtubule/Tubulin) 聚合并导致细胞周期停滞和凋亡 (apoptosis)。

Tubulysin I                                          (Synonyms: 微管蛋白抑制剂 I)

Tubulysin I Chemical Structure

CAS No. : 799822-10-9

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Tubulysin I 相关产品

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生物活性

Tubulysin I is a highly cytotoxic anti-microtubule toxin (anti-microtubule toxins) that is synthesized as an ADC cytotoxin (ADC Cytotoxin). Tubulysin I can be isolated from the myxobacteria Archangium geophyra and Angiococcus disciformis. Tubulysin I displays extremely potent cytotoxic activity in mammalian cells, including multidrug-resistant cell lines, with IC50 values in the low nanomolar range. Tubulysin I inhibits microtubule/tubulin polymerization and leads to cell cycle arrest and apoptosis[1][2].

分子量

801.99

Formula

C40H59N5O10S

CAS 号

799822-10-9

中文名称

微管蛋白抑制剂 I

结构分类
  • Phenols
  • Monophenols
  • Ketones, Aldehydes, Acids
初始来源
  • 微生物

Myxobacteria

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
Data Sheet (531 KB) 产品使用指南 (1538 KB)

参考文献
  • [1]. Kubicek K, et al. The tubulin-bound structure of the antimitotic drug tubulysin. Angew Chem Int Ed Engl. 2010 Jun 28;49(28):4809-12.  [Content Brief]

    [2]. Vlahov IR, et al. Acid mediated formation of an N-acyliminium ion from tubulysins: a new methodology for the synthesis of natural tubulysins and their analogs. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6778-81.  [Content Brief]

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