上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物，专注于信号通路和疾病研究领域。
Lasiocarpine
Lasiocarpine 是一种有肝毒性吡咯里西定生物碱 ( hepatotoxic PA)，在体内可引起致命的肝静脉闭塞性疾病。Lasiocarpine 只有在代谢转化为毒性中间体后才有毒性，包括 Dehydrolasiocarpine 和 N-oxide。
Lasiocarpine Chemical Structure
CAS No. : 303-34-4
| 规格 | 价格 | 是否有货 | |
|---|---|---|---|
| 5 mg | ￥7200 | 询问价格 & 货期 | |
* Please select Quantity before adding items.
| 生物活性 |
Lasiocarpine, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide[1]. |
|---|---|
| 体外研究 (In Vitro) |
Lasiocarpine is toxic only after its metabolic conversion to the toxic intermediate, known as dehydrolasiocarpine[1].Dehydrolasiocarpine and other putative didehydropyrrolizidine alkaloids (the pyrrolic esters) are very reactive,they attack nucleophilic macromolecules such as DNA and proteins, eliciting severe toxicities, including liver veno-occlusive disease and tumors[1].Lasiocarpine is mainly metabolized in vitro through five metabolic pathways, dehydrogenation, ester bond cleavage, demethylation[1]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
411.49 |
| Formula |
C21H33NO7 |
| CAS 号 |
303-34-4 |
| 结构分类 |
|
| 初始来源 |
|
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 纯度 & 产品资料 |
Data Sheet (532 KB) 产品使用指南 (1538 KB)
|
| 参考文献 |
|
所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务