Sappanchalcone

上海金畔生物科技有限公司为生命科学和医药研发人员提供生物活性分子抑制剂、激动剂、特异性抑制剂、化合物库、重组蛋白、同位素标记物,专注于信号通路和疾病研究领域。
Sappanchalcone  纯度: 99.62%

Sappanchalcone 从 Caesalpinia sappan L. 中提取的黄酮类化合物,诱导人结肠癌细胞凋亡 (apoptosis)。

Sappanchalcone

Sappanchalcone Chemical Structure

CAS No. : 94344-54-4

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5 mg ¥9800 In-stock
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Sappanchalcone 相关产品

相关化合物库:

  • Natural Product Library Plus
  • Bioactive Compound Library Plus

同靶点产品:

同靶点蛋白产品:

生物活性

Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells[1].

体外研究
(In Vitro)

Sappanchalcone has a statistically significant effect on HCT116 cells than on SW480 cells (IC50= 37.33 μM and 54.23 μM, respectively). Sappanchalcone reduces MMP with a significant increase in ROS levels in human colon cancer cells. Sappanchalcone triggered phosphorylation of p53, which is involved in the activation of caspases and increased expression of Bax in HCT116 cells[1].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Sappanchalcone 相关抗体:

分子量

286.28

Formula

C16H14O5

CAS 号

94344-54-4

性状

固体

颜色

Light yellow to yellow

结构分类
  • Flavonoids
  • Chalcones
  • Phenols
  • Polyphenols
初始来源
  • 植物
  • 豆科
  • 苏木
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: 99.62%

Data Sheet (523 KB) SDS (251 KB)

COA (261 KB) HNMR (154 KB) LCMS (143 KB)

产品使用指南 (1538 KB)

参考文献
  • [1]. Seo HW, et al. Sappanchalcone, a flavonoid isolated from Caesalpinia sappan L., induces caspase-dependent and AIF-dependent apoptosis in human colon cancer cells. Chem Biol Interact. 2020;327:109185.  [Content Brief]

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